Bitter orange/synephrine In Pakistan - Native to eastern Africa, the Arabian Peninsula, Syria, and Southeast Asia, bitter orange now is grown throughout the Mediterranean region and elsewhere, including California and Florida.
Bitter orange is likely safe when used orally in amounts commonly found in foods.
There is one case report of a woman having a faster-than-normal heart rate at rest after taking a dietary supplement that contained only bitter orange. There are other case reports of healthy people experiencing fainting, angina, heart attack, and stroke after taking bitter orange as part of multicomponent products. However, because these products contained multiple ingredients, it is difficult to know the role that bitter orange played.
Evidence regarding the effects of bitter orange (alone or combined with other substances, such as caffeine and green tea) on the heart and cardiovascular system is inconclusive. Some studies showed that bitter orange raised blood pressure and heart rate, but other studies showed that bitter orange didn’t have this effect at commonly used doses.
Some sources list bitter orange as a stimulant whereas other sources say that it’s not a stimulant at commonly used doses.
Little is known about whether it’s safe to use bitter orange during pregnancy or while breastfeeding.
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